| Function | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries. |
| Protein Name | Phosphatidylinositide Phosphatase Sac2Inositol Polyphosphate 5-Phosphatase FSac Domain-Containing Inositol Phosphatase 2Sac Domain-Containing Phosphoinositide 4-Phosphatase 2Hsac2 |
| Database Links | Reactome: R-HSA-1660516 |
| Cellular Localisation | MembraneClathrin-Coated PitEarly EndosomeRecycling EndosomeAlso Found On Macropinosomes |
| Alternative Antibody Names | Anti-Phosphatidylinositide Phosphatase Sac2 antibodyAnti-Inositol Polyphosphate 5-Phosphatase F antibodyAnti-Sac Domain-Containing Inositol Phosphatase 2 antibodyAnti-Sac Domain-Containing Phosphoinositide 4-Phosphatase 2 antibodyAnti-Hsac2 antibodyAnti-INPP5F antibodyAnti-KIAA0966 antibodyAnti-SAC2 antibodyAnti-MSTP007 antibodyAnti-MSTP047 antibody |
Information sourced from Uniprot.org
