| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phosphatidylinositol polyphosphate 5-phosphatase type IV (490-570 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INPP5E |
| Gene ID: | 56623 |
| Uniprot ID: | INP5E_HUMAN |
| Immunogen Region: | 490-570 aa |
| Specificity: | INP5E Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 490-570 |
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability. |
| Protein Name | Phosphatidylinositol Polyphosphate 5-Phosphatase Type Iv 72 Kda Inositol Polyphosphate 5-Phosphatase Inositol Polyphosphate-5-Phosphatase E Phosphatidylinositol 4 -5-Bisphosphate 5-Phosphatase Phosphatidylinositol-3 -4 -5-Trisphosphate 5-Phosphatase |
| Database Links | Reactome: R-HSA-1660514 Reactome: R-HSA-5624958 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cilium Axoneme Golgi Apparatus Golgi Stack Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Membrane Cell Projection Ruffle Nucleus Peripheral Membrane Protein Associated With Golgi Stacks |
| Alternative Antibody Names | Anti-Phosphatidylinositol Polyphosphate 5-Phosphatase Type Iv antibody Anti-72 Kda Inositol Polyphosphate 5-Phosphatase antibody Anti-Inositol Polyphosphate-5-Phosphatase E antibody Anti-Phosphatidylinositol 4 -5-Bisphosphate 5-Phosphatase antibody Anti-Phosphatidylinositol-3 -4 -5-Trisphosphate 5-Phosphatase antibody Anti-INPP5E antibody |
Information sourced from Uniprot.org