| Short Description : | Rabbit polyclonal ING5 (1-220) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ING5 |
| Gene ID: | 84289 |
| Uniprot ID: | ING5_HUMAN |
| Immunogen Region: | 1-220 |
| Immunogen Sequence: | MATAMYLEHYLDSIENLPCE LQRNFQLMRELDQRTEDKKA EIDILAAEYISTVKTLSPDQ RVERLQKIQNAYSKCKEYSD DKVQLAMQTYEMVDKHIRRL DADLARFEADLKDKMEGSDF ESSGGRGLKKGRGQKEKRGS RGRGRRTSEEDTPKKKKHKG GSEFTDTILSVHPSDVLDMP VDPNEPTYCLCHQVSYGEMI GCDNPDCPIEWFHFACVDLT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ING5 (NP_115705.2). |
| Tissue Specificity | Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells. |
| Function | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner. |
| Protein Name | Inhibitor Of Growth Protein 5P28ing5 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-6804758 |
| Cellular Localisation | NucleusChromosomeLocalizes To Transcription Start Sites |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 5 antibodyAnti-P28ing5 antibodyAnti-ING5 antibody |
Information sourced from Uniprot.org
