Anti-INCA1 antibody (10-60 aa) (STJ194338)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human INCA1 at the amino acid range 10-60
General Information
| Short Description | Rabbit polyclonal anti-Protein INCA1 (10-60 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INCA1 |
| Gene ID | 388324 |
| Uniprot ID | INCA1_HUMAN |
| Immunogen | Synthesized peptide derived from the human INCA1 at the amino acid range 10-60 |
| Immunogen Region | 10-60 aa |
| Specificity | This antibody detects endogenous levels of INCA1 at Human/Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues. |
| Function | Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2.binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth. |
| Protein Name | Protein Inca1Inhibitor Of Cdk Interacting With Cyclin A1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Protein Inca1 antibodyAnti-Inhibitor Of Cdk Interacting With Cyclin A1 antibodyAnti-INCA1 antibodyAnti-HSD45 antibody |
Information sourced from Uniprot.org