| Short Description : | Rabbit polyclonal ILKAP (1-392) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ILKAP |
| Gene ID: | 80895 |
| Uniprot ID: | ILKAP_HUMAN |
| Immunogen Region: | 1-392 |
| Immunogen Sequence: | MDLFGDLPEPERSPRPAAGK EAQKGPLLFDDLPPASSTDS GSGGPLLFDDLPPASSGDSG SLATSISQMVKTEGKGAKRK TSEEEKNGSEELVEKKVCKA SSVIFGLKGYVAERKGEREE MQDAHVILNDITEECRPPSS LITRVSYFAVFDGHGGIRAS KFAAQNLHQNLIRKFPKGDV ISVEKTVKRCLLDTFKHTDE EFLKQASSQKPAWKDGSTAT CVLAVDNILYIANLGDSRA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-392 of human ILKAP (NP_110395.1). |
| Tissue Specificity | Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. |
| Function | Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. |
| Protein Name | Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2cIlkap |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2c antibodyAnti-Ilkap antibodyAnti-ILKAP antibody |
Information sourced from Uniprot.org
