| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Interleukin-36 beta (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL36B |
| Gene ID: |
27177 |
| Uniprot ID: |
IL36B_HUMAN |
| Immunogen Region: |
111-160 aa |
| Specificity: |
IL-1F8 Polyclonal Antibody detects endogenous levels of IL-1F8 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the C-terminal region of human IL36B at the amino acid range 111-160 |
| Post Translational Modifications | N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. |
| Protein Name | Interleukin-36 BetaFil1 EtaInterleukin-1 EtaIl-1 EtaInterleukin-1 Family Member 8Il-1f8Interleukin-1 Homolog 2Il-1h2 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-36 Beta antibodyAnti-Fil1 Eta antibodyAnti-Interleukin-1 Eta antibodyAnti-Il-1 Eta antibodyAnti-Interleukin-1 Family Member 8 antibodyAnti-Il-1f8 antibodyAnti-Interleukin-1 Homolog 2 antibodyAnti-Il-1h2 antibodyAnti-IL36B antibodyAnti-IL1F8 antibodyAnti-IL1H2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
