| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Monoclonal |
| Clone ID: | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | Il12b |
| Gene ID: | 16160 |
| Uniprot ID: | IL12B_MOUSE |
| Immunogen Region: | 23-335 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-335 of mouse IL12B (NP_001290173.1). |
| Immunogen Sequence: | MWELEKDVYVVEVDWTPDAP GETVNLTCDTPEEDDITWTS DQRHGVIGSGKTLTITVKEF LDAGQYTCHKGGETLSHSHL LLHKKENGIWSTEILKNFKN KTFLKCEAPNYSGRFTCSWL VQRNMDLKFNIKSSSSSPDS RAVTCGMASLSAEKVTLDQR DYEKYSVSCQEDVTCPTAEE TLPIELALEARQQNKYENYS TSFFIRDIIKPDPPKNLQMK PLKNSQVEVSWEYPDSWST |
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit Beta Il-12b Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit Clmf P40 Il-12 Subunit P40 |
| Database Links | Reactome: R-MMU-9020591 Reactome: -MMU-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-12 Subunit Beta antibody Anti-Il-12b antibody Anti-Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibody Anti-Clmf P40 antibody Anti-Il-12 Subunit P40 antibody Anti-Il12b antibody |
Information sourced from Uniprot.org
