| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:6000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Il12b |
| Gene ID: |
16160 |
| Uniprot ID: |
IL12B_MOUSE |
| Immunogen Region: |
23-335 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-335 of mouse IL12B (NP_001290173.1). |
| Immunogen Sequence: |
MWELEKDVYVVEVDWTPDAP GETVNLTCDTPEEDDITWTS DQRHGVIGSGKTLTITVKEF LDAGQYTCHKGGETLSHSHL LLHKKENGIWSTEILKNFKN KTFLKCEAPNYSGRFTCSWL VQRNMDLKFNIKSSSSSPDS RAVTCGMASLSAEKVTLDQR DYEKYSVSCQEDVTCPTAEE TLPIELALEARQQNKYENYS TSFFIRDIIKPDPPKNLQMK PLKNSQVEVSWEYPDSWST |
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40 |
| Database Links | Reactome: R-MMU-9020591Reactome: -MMU-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-12 Subunit Beta antibodyAnti-Il-12b antibodyAnti-Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibodyAnti-Clmf P40 antibodyAnti-Il-12 Subunit P40 antibodyAnti-Il12b antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
