Anti-IL-15 antibody (70-82) (STJ72889)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-IL-15 (70-82) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 23kDa band observed in Human Bone Marrow lysates (calculated MW of 18.1kDa according to NP_000576.1). The observed molecular weight corresponds to the glycosylated form. Recomm |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | IL15 |
| Gene ID | 3600 |
| Uniprot ID | IL15_HUMAN |
| Accession Number | NP_000576.1; NP_751915.1 |
| Immunogen Region | 70-82 |
| Immunogen Sequence | DATLYTESDVHPS |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_000576.1; NP_751915.1). |
Additional Info
| Function | Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4. |
| Protein Name | Interleukin-15Il-15 |
| Database Links | Reactome: R-HSA-8983432 |
| Cellular Localisation | Isoform Il15-S48aa: SecretedIsoform Il15-S21aa: CytoplasmNucleusIl15-S21aa Is Not SecretedBut Rather Is Stored IntracellularlyAppearing In The Nucleus And Cytoplasmic Components |
| Alternative Antibody Names | Anti-Interleukin-15 antibodyAnti-Il-15 antibodyAnti-IL15 antibody |
Information sourced from Uniprot.org