• Western blot analysis of extracts of various cell lines, using IGFBP6 antibody (STJ112233) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.

Anti-IGFBP6 antibody (28-240) (STJ112233)

SKU:
STJ112233

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IGFBP6 (28-240) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:3000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IGFBP6
Gene ID: 3489
Uniprot ID: IBP6_HUMAN
Immunogen Region: 28-240
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 28-240 of human IGFBP6 (NP_002169.1).
Immunogen Sequence: RCPGCGQGVQAGCPGGCVEE EDGGSPAEGCAEAEGCLRRE GQECGVYTPNCAPGLQCHPP KDDEAPLRALLLGRGRCLPA RAPAVAEENPKESKPQAGTA RPQDVNRRDQQRNPGTSTTP SQPNSAGVQDTEMGPCRRHL DSVLQQLQTEVYRGAQTLYV PNCDHRGFYRKRQCRSSQGQ RRGPCWCVDRMGKSLPGSPD GNGSSSCPTGSSG
Post Translational Modifications O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
Protein Name Insulin-Like Growth Factor-Binding Protein 6
Ibp-6
Igf-Binding Protein 6
Igfbp-6
Database Links Reactome: R-HSA-381426
Cellular Localisation Secreted
Alternative Antibody Names Anti-Insulin-Like Growth Factor-Binding Protein 6 antibody
Anti-Ibp-6 antibody
Anti-Igf-Binding Protein 6 antibody
Anti-Igfbp-6 antibody
Anti-IGFBP6 antibody
Anti-IBP6 antibody

Information sourced from Uniprot.org

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