| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IGFBP6 (28-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:3000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IGFBP6 |
| Gene ID: |
3489 |
| Uniprot ID: |
IBP6_HUMAN |
| Immunogen Region: |
28-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-240 of human IGFBP6 (NP_002169.1). |
| Immunogen Sequence: |
RCPGCGQGVQAGCPGGCVEE EDGGSPAEGCAEAEGCLRRE GQECGVYTPNCAPGLQCHPP KDDEAPLRALLLGRGRCLPA RAPAVAEENPKESKPQAGTA RPQDVNRRDQQRNPGTSTTP SQPNSAGVQDTEMGPCRRHL DSVLQQLQTEVYRGAQTLYV PNCDHRGFYRKRQCRSSQGQ RRGPCWCVDRMGKSLPGSPD GNGSSSCPTGSSG |
| Post Translational Modifications | O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid. |
| Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 6Ibp-6Igf-Binding Protein 6Igfbp-6 |
| Database Links | Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor-Binding Protein 6 antibodyAnti-Ibp-6 antibodyAnti-Igf-Binding Protein 6 antibodyAnti-Igfbp-6 antibodyAnti-IGFBP6 antibodyAnti-IBP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
