| Short Description : | Rabbit polyclonal anti-Intraflagellar transport protein 122 homolog (956-1006 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IFT122 |
| Gene ID: | 55764 |
| Uniprot ID: | IF122_HUMAN |
| Immunogen: | Synthesized peptide derived from the human IF122 at the amino acid range 956-1006 |
| Immunogen Region: | 956-1006 aa |
| Specificity: | This antibody detects endogenous levels of IF122 at Human/Mouse |
| Function | As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia. |
| Protein Name | Intraflagellar Transport Protein 122 HomologWd Repeat-Containing Protein 10Wd Repeat-Containing Protein 140 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyLocalizes To Photoreceptor Connecting Cilia |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 122 Homolog antibodyAnti-Wd Repeat-Containing Protein 10 antibodyAnti-Wd Repeat-Containing Protein 140 antibodyAnti-IFT122 antibodyAnti-SPG antibodyAnti-WDR10 antibodyAnti-WDR140 antibody |
Information sourced from Uniprot.org
