| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IFNGR2 (221-322) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFNGR2 |
| Gene ID: |
3460 |
| Uniprot ID: |
INGR2_HUMAN |
| Immunogen Region: |
221-322 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 221-322 of human IFNGR2 (NP_005525.2). |
| Immunogen Sequence: |
SNIFRVGHLSNISCYETMAD ASTELQQVILISVGTFSLLS VLAGACFFLVLKYRGLIKYW FHTPPSIPLQIEEYLKDPTQ PILEALDKDSSPKDDVWDSV SI |
| Tissue Specificity | Expressed in T-cells (at protein level). |
| Function | Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. |
| Protein Name | Interferon Gamma Receptor 2Ifn-Gamma Receptor 2Ifn-Gamma-R2Interferon Gamma Receptor Accessory Factor 1Af-1Interferon Gamma Receptor Beta-ChainIfn-Gamma-R-BetaInterferon Gamma Transducer 1 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-9679191Reactome: R-HSA-9732724 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmic Vesicle MembraneGolgi Apparatus MembraneEndoplasmic Reticulum MembraneCytoplasmHas Low Cell Surface Expression And High Cytoplasmic Expression In T CellsThe Bias Towards Cytoplasmic Expression May Be Due To Ligand-Independent Receptor Internalization And Recycling |
| Alternative Antibody Names | Anti-Interferon Gamma Receptor 2 antibodyAnti-Ifn-Gamma Receptor 2 antibodyAnti-Ifn-Gamma-R2 antibodyAnti-Interferon Gamma Receptor Accessory Factor 1 antibodyAnti-Af-1 antibodyAnti-Interferon Gamma Receptor Beta-Chain antibodyAnti-Ifn-Gamma-R-Beta antibodyAnti-Interferon Gamma Transducer 1 antibodyAnti-IFNGR2 antibodyAnti-IFNGT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and SPK knockout (KO) 293T cells, using [KO Validated] SPK Rabbit polyclonal antibody (STJ11100823) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89759/358235/STJ11100823_1__81500.1713122567.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SPK knockout (KO) 293T cells, using [KO Validated] SPK Rabbit polyclonal antibody (STJ11100823) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")