| Tissue Specificity | Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. |
| Function | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. |
| Protein Name | Serine Protease Htra3High-Temperature Requirement Factor A3Pregnancy-Related Serine Protease |
| Cellular Localisation | SecretedSecretion Increased During Decidualization Of Endometrial Stromal Cells |
| Alternative Antibody Names | Anti-Serine Protease Htra3 antibodyAnti-High-Temperature Requirement Factor A3 antibodyAnti-Pregnancy-Related Serine Protease antibodyAnti-HTRA3 antibodyAnti-PRSP antibody |
Information sourced from Uniprot.org
