Anti-HTRA3 antibody (334-453) (STJ116855)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HTRA3 (334-453) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HTRA3 |
| Gene ID | 94031 |
| Uniprot ID | HTRA3_HUMAN |
| Immunogen Region | 334-453 |
| Immunogen Sequence | SDRITRFLTEFQDKQIKDWK KRFIGIRMRTITPSLVDELK ASNPDFPEVSSGIYVQEVAP NSPSQRGGIQDGDIIVKVNG RPLVDSSELQEAVLTESPLL LEVRRGNDDLLFSIAPEVVM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1). |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. |
| Function | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. |
| Protein Name | Serine Protease Htra3High-Temperature Requirement Factor A3Pregnancy-Related Serine Protease |
| Database Links | |
| Cellular Localisation | SecretedSecretion Increased During Decidualization Of Endometrial Stromal Cells |
| Alternative Antibody Names | Anti-Serine Protease Htra3 antibodyAnti-High-Temperature Requirement Factor A3 antibodyAnti-Pregnancy-Related Serine Protease antibodyAnti-HTRA3 antibodyAnti-PRSP antibody |
Information sourced from Uniprot.org