Anti-HTR2A antibody (1-100) (STJ11103369)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HTR2A (1-100) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HTR2A |
| Gene ID | 3356 |
| Uniprot ID | 5HT2A_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MDILCEENTSLSSTTNSLMQ LNDDTRLYSNDFNSGEANTS DAFNWTVDSENRTNLSCEGC LSPSCLSLLHLQEKNWSALL TAVVIILTIAGNILVIMAVS |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HTR2A (NP_000612.1). |
Additional Info
| Tissue Specificity | Detected in brain cortex (at protein level). Detected in blood platelets. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. |
| Protein Name | 5-Hydroxytryptamine Receptor 2a5-Ht-25-Ht-2aSerotonin Receptor 2a |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendriteAxonCytoplasmic VesicleMembraneCaveolaPresynapse |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 2a antibodyAnti-5-Ht-2 antibodyAnti-5-Ht-2a antibodyAnti-Serotonin Receptor 2a antibodyAnti-HTR2A antibodyAnti-HTR2 antibody |
Information sourced from Uniprot.org