| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-5-hydroxytryptamine receptor 2A (422-471 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HTR2A |
| Gene ID: |
3356 |
| Uniprot ID: |
5HT2A_HUMAN |
| Immunogen Region: |
422-471 aa |
| Specificity: |
SR-2A Polyclonal Antibody detects endogenous levels of SR-2A protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human 5-HT-2A at the amino acid range 422-471 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. |
| Protein Name | 5-Hydroxytryptamine Receptor 2a5-Ht-25-Ht-2aSerotonin Receptor 2a |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendriteAxonCytoplasmic VesicleMembraneCaveolaPresynapse |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 2a antibodyAnti-5-Ht-2 antibodyAnti-5-Ht-2a antibodyAnti-Serotonin Receptor 2a antibodyAnti-HTR2A antibodyAnti-HTR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
