Anti-HTR1B antibody (201-250 aa) (STJ95758)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human 5-HT-1B at the amino acid range 201-250
General Information
| Short Description | Rabbit polyclonal anti-5-hydroxytryptamine receptor 1B (201-250 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HTR1B |
| Gene ID | 3351 |
| Uniprot ID | 5HT1B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human 5-HT-1B at the amino acid range 201-250 |
| Immunogen Region | 201-250 aa |
| Specificity | SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
| Protein Name | 5-Hydroxytryptamine Receptor 1b5-Ht-1b5-Ht1bS12Serotonin 1d Beta Receptor5-Ht-1d-BetaSerotonin Receptor 1b |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1b antibodyAnti-5-Ht-1b antibodyAnti-5-Ht1b antibodyAnti-S12 antibodyAnti-Serotonin 1d Beta Receptor antibodyAnti-5-Ht-1d-Beta antibodyAnti-Serotonin Receptor 1b antibodyAnti-HTR1B antibodyAnti-HTR1DB antibody |
Information sourced from Uniprot.org