Anti-HSULF-1/sulfatase 1 antibody (Internal) (STJ73257)

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STJ73257-100
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Covered by St John's Laboratory Guarantee

Host: Goat
Applications: Pep-ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-HSULF-1/sulfatase 1 (Internal) is suitable for use in ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:128000.
WB: Preliminary experiments in Human Colon, Heart, Kidney, Lung, Overy and Prostrate lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SULF1
Gene ID: 23213
Uniprot ID: SULF1_HUMAN
Immunogen Region: Internal
Accession Number: NP_055985.2
Specificity: Reported variants NP_055985.2; NP_001121676.1; NP_001121677.1; NP_001121678.1 represent identical protein
Immunogen Sequence: RGFHDKDKECS
Post Translational Modifications Processing by furin produces a secreted form. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Function Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
Protein Name Extracellular Sulfatase Sulf-1
Hsulf-1
Arylsulfatase
N-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form
Cellular Localisation Endoplasmic Reticulum
Golgi Apparatus
Golgi Stack
Cell Surface
Extracellular Sulfatase Sulf-2 Secreted Form: Secreted
Alternative Antibody Names Anti-Extracellular Sulfatase Sulf-1 antibody
Anti-Hsulf-1 antibody
Anti-Arylsulfatase antibody
Anti-N-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form antibody
Anti-SULF1 antibody
Anti-KIAA1077 antibody

Information sourced from Uniprot.org

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