Host: | Goat |
Applications: | Pep-ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Goat polyclonal antibody anti-HSULF-1/sulfatase 1 (Internal) is suitable for use in ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Preliminary experiments in Human Colon, Heart, Kidney, Lung, Overy and Prostrate lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | SULF1 |
Gene ID: | 23213 |
Uniprot ID: | SULF1_HUMAN |
Immunogen Region: | Internal |
Accession Number: | NP_055985.2 |
Specificity: | Reported variants NP_055985.2; NP_001121676.1; NP_001121677.1; NP_001121678.1 represent identical protein |
Immunogen Sequence: | RGFHDKDKECS |
Post Translational Modifications | Processing by furin produces a secreted form. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
Function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. |
Protein Name | Extracellular Sulfatase Sulf-1Hsulf-1ArylsulfataseN-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form |
Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusGolgi StackCell SurfaceExtracellular Sulfatase Sulf-2 Secreted Form: Secreted |
Alternative Antibody Names | Anti-Extracellular Sulfatase Sulf-1 antibodyAnti-Hsulf-1 antibodyAnti-Arylsulfatase antibodyAnti-N-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form antibodyAnti-SULF1 antibodyAnti-KIAA1077 antibody |
Information sourced from Uniprot.org