Anti-HRASLS3/HREV107-3 antibody (N-Term) (STJ71468)

SKU:
STJ71468-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-HRASLS3/HREV107-3 (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-5µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: PLAAT3
Gene ID: 11145
Uniprot ID: PLAT3_HUMAN
Immunogen Region: N-Term
Accession Number: NP_009000.2
Specificity: Reported variants represent identical protein:NP_009000.2 and NP_001121675.1).
Immunogen Sequence: RAPIPEPKPGDLIE
Function Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity. Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity. (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm. May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection. Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome. May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery. The lipid-modifying enzyme activity is required for this process.
Protein Name Phospholipase A And Acyltransferase 3
Adipose-Specific Phospholipase A2
Adpla
Group Xvi Phospholipase A1/A2
H-Rev 107 Protein Homolog
H-Rev107
Hrev107-1
Hras-Like Suppressor 1
Hras-Like Suppressor 3
Hrsl3
Hrev107-3
Renal Carcinoma Antigen Ny-Ren-65
Database Links Reactome: R-HSA-1482788
Reactome: R-HSA-1482801
Reactome: R-HSA-1482839
Reactome: R-HSA-1482922
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Cytoplasm
Cytosol
Perinuclear Region
Peroxisome Membrane
Mitochondrion Membrane
Nucleus Envelope
Lysosome Membrane
Endoplasmic Reticulum Membrane
During Eye Lens Differentiation
Recruited From The Cytosol To Various Organelles
Including Mitochondria
Endoplasmic Reticulum
Nuclear Envelope And Lysosomes
Immediately Before Organelle Degradation
This Translocation Is Triggered By Organelle Membrane Damage And Requires The C-Terminal Transmembrane Domain
Alternative Antibody Names Anti-Phospholipase A And Acyltransferase 3 antibody
Anti-Adipose-Specific Phospholipase A2 antibody
Anti-Adpla antibody
Anti-Group Xvi Phospholipase A1/A2 antibody
Anti-H-Rev 107 Protein Homolog antibody
Anti-H-Rev107 antibody
Anti-Hrev107-1 antibody
Anti-Hras-Like Suppressor 1 antibody
Anti-Hras-Like Suppressor 3 antibody
Anti-Hrsl3 antibody
Anti-Hrev107-3 antibody
Anti-Renal Carcinoma Antigen Ny-Ren-65 antibody
Anti-PLAAT3 antibody
Anti-HRASLS3 antibody
Anti-HREV107 antibody
Anti-PLA2G16 antibody

Information sourced from Uniprot.org

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