| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HOMER3 (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:2000 is recommended fro WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Homer3 |
| Gene ID: |
26558 |
| Uniprot ID: |
HOME3_MOUSE |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for Homer3. |
| Immunogen: |
A synthetic peptide from the internal region of rat HOMER3 conjugated to blue carrier protein was used as the antigen. |
| Function | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA. |
| Protein Name | Homer Protein Homolog 3Homer-3 |
| Database Links | Reactome: R-MMU-6794361 |
| Cellular Localisation | CytoplasmPostsynaptic DensitySynapsePostsynaptic Density Of Neuronal Cells |
| Alternative Antibody Names | Anti-Homer Protein Homolog 3 antibodyAnti-Homer-3 antibodyAnti-Homer3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
