| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells. |
| Post Translational Modifications | Dimethylation of Arg-408 is probably of the asymmetric type. |
| Function | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. |
| Protein Name | Heterogeneous Nuclear Ribonucleoprotein D-LikeHnrnp D-LikeHnrnp DlAu-Rich Element Rna-Binding FactorJkt41-Binding ProteinProtein Laauf1 |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm In A Tnpo1-Dependent Manner |
| Alternative Antibody Names | Anti-Heterogeneous Nuclear Ribonucleoprotein D-Like antibodyAnti-Hnrnp D-Like antibodyAnti-Hnrnp Dl antibodyAnti-Au-Rich Element Rna-Binding Factor antibodyAnti-Jkt41-Binding Protein antibodyAnti-Protein Laauf1 antibodyAnti-HNRNPDL antibodyAnti-HNRPDL antibodyAnti-JKTBP antibody |
Information sourced from Uniprot.org
