| Short Description : | Rabbit polyclonal HMG20A (1-347) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:100-1:500IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HMG20A |
| Gene ID: | 10363 |
| Uniprot ID: | HM20A_HUMAN |
| Immunogen Region: | 1-347 |
| Immunogen Sequence: | MENLMTSSTLPPLFADEDGS KESNDLATTGLNHPEVPYSS GATSSTNNPEFVEDLSQGQL LQSESSNAAEGNEQRHEDEQ RSKRGGWSKGRKRKKPLRDS NAPKSPLTGYVRFMNERREQ LRAKRPEVPFPEITRMLGNE WSKLPPEEKQRYLDEADRDK ERYMKELEQYQKTEAYKVFS RKTQDRQKGKSHRQDAARQA THDHEKETEVKERSVFDIPI FTEEFLNHSKAREAELRQL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-347 of human HMG20A (NP_060670.1). |
| Tissue Specificity | Ubiquitous. |
| Function | Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4. |
| Protein Name | High Mobility Group Protein 20aHmg Box-Containing Protein 20aHmg Domain-Containing Protein 1Hmg Domain-Containing Protein Hmgx1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-High Mobility Group Protein 20a antibodyAnti-Hmg Box-Containing Protein 20a antibodyAnti-Hmg Domain-Containing Protein 1 antibodyAnti-Hmg Domain-Containing Protein Hmgx1 antibodyAnti-HMG20A antibodyAnti-HMGX1 antibodyAnti-HMGXB1 antibody |
Information sourced from Uniprot.org
