| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Porphobilinogen deaminase is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HMBS |
| Gene ID: | 3145 |
| Uniprot ID: | HEM3_HUMAN |
| Specificity: | This antibody detects endogenous levels of HMBS at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human HMBS |
| Function | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact. |
| Protein Name | Porphobilinogen Deaminase Pbg-D Hydroxymethylbilane Synthase Hmbs Pre-Uroporphyrinogen Synthase |
| Database Links | Reactome: R-HSA-189451 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Porphobilinogen Deaminase antibody Anti-Pbg-D antibody Anti-Hydroxymethylbilane Synthase antibody Anti-Hmbs antibody Anti-Pre-Uroporphyrinogen Synthase antibody Anti-HMBS antibody Anti-PBGD antibody Anti-UPS antibody |
Information sourced from Uniprot.org