Anti-HIP1 antibody (410-690) (STJ29001)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HIP1 (410-690) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HIP1 |
| Gene ID | 3092 |
| Uniprot ID | HIP1_HUMAN |
| Immunogen Region | 410-690 |
| Immunogen Sequence | SELEADLAEQQHLRQQAADD CEFLRAELDELRRQREDTEK AQRSLSEIERKAQANEQRYS KLKEKYSELVQNHADLLRKN AEVTKQVSMARQAQVDLERE KKELEDSLERISDQGQRKTQ EQLEVLESLKQELATSQREL QVLQGSLETSAQSEANWAAE FAELEKERDSLVSGAAHREE ELSALRKELQDTQLKLASTE ESMCQLAKDQRKMLLVGSRK AAEQVIQDALNQLEEPPLI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 410-690 of human HIP1 (NP_005329.3). |
Additional Info
| Tissue Specificity | Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. |
| Function | Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. |
| Protein Name | Huntingtin-Interacting Protein 1Hip-1Huntingtin-Interacting Protein IHip-I |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusEndomembrane SystemCytoplasmic VesicleClathrin-Coated Vesicle MembraneShuttles Between Cytoplasm And NucleusNuclear Translocation Can Be Induced By Ar |
| Alternative Antibody Names | Anti-Huntingtin-Interacting Protein 1 antibodyAnti-Hip-1 antibodyAnti-Huntingtin-Interacting Protein I antibodyAnti-Hip-I antibodyAnti-HIP1 antibody |
Information sourced from Uniprot.org