| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HIP1 (410-690) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HIP1 |
| Gene ID: |
3092 |
| Uniprot ID: |
HIP1_HUMAN |
| Immunogen Region: |
410-690 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 410-690 of human HIP1 (NP_005329.3). |
| Immunogen Sequence: |
SELEADLAEQQHLRQQAADD CEFLRAELDELRRQREDTEK AQRSLSEIERKAQANEQRYS KLKEKYSELVQNHADLLRKN AEVTKQVSMARQAQVDLERE KKELEDSLERISDQGQRKTQ EQLEVLESLKQELATSQREL QVLQGSLETSAQSEANWAAE FAELEKERDSLVSGAAHREE ELSALRKELQDTQLKLASTE ESMCQLAKDQRKMLLVGSRK AAEQVIQDALNQLEEPPLI |
| Tissue Specificity | Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. |
| Function | Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. |
| Protein Name | Huntingtin-Interacting Protein 1Hip-1Huntingtin-Interacting Protein IHip-I |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusEndomembrane SystemCytoplasmic VesicleClathrin-Coated Vesicle MembraneShuttles Between Cytoplasm And NucleusNuclear Translocation Can Be Induced By Ar |
| Alternative Antibody Names | Anti-Huntingtin-Interacting Protein 1 antibodyAnti-Hip-1 antibodyAnti-Huntingtin-Interacting Protein I antibodyAnti-Hip-I antibodyAnti-HIP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
