| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HEXA |
| Gene ID: | 3073 |
| Uniprot ID: | HEXA_HUMAN |
| Immunogen Region: | 270-529 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2). |
| Immunogen Sequence: | IPGLLTPCYSGSEPSGTFGP VNPSLNNTYEFMSTFFLEVS SVFPDFYLHLGGDEVDFTCW KSNPEIQDFMRKKGFGEDFK QLESFYIQTLLDIVSSYGKG YVVWQEVFDNKVKIQPDTII QVWREDIPVNYMKELELVTK AGFRALLSAPWYLNRISYGP DWKDFYIVEPLAFEGTPEQK ALVIGGEACMWGEYVDNTNL VPRLWPRAGAVAERLWSNKL TSDLTFAYERLSHFRCELL |
| Post Translational Modifications | N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2) (Probable). N-linked glycan at Asn-157 consists of either GlcNAc or GlcNAc(2)-Man(7-9). N-linked glycan at Asn-295 consists of either GlcNAc, GlcNAc-Fuc, or GlcNAc(2)-Man(4) (Probable). |
| Function | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. |
| Protein Name | Beta-Hexosaminidase Subunit Alpha Beta-N-Acetylhexosaminidase Subunit Alpha Hexosaminidase Subunit A N-Acetyl-Beta-Glucosaminidase Subunit Alpha |
| Database Links | Reactome: R-HSA-2022857 Reactome: R-HSA-2024101 Reactome: R-HSA-2160916 Reactome: R-HSA-3656234 Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Beta-Hexosaminidase Subunit Alpha antibody Anti-Beta-N-Acetylhexosaminidase Subunit Alpha antibody Anti-Hexosaminidase Subunit A antibody Anti-N-Acetyl-Beta-Glucosaminidase Subunit Alpha antibody Anti-HEXA antibody |
Information sourced from Uniprot.org