| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylated with SUMO1. Sumoylation prevents binding to chromatin. Phosphorylation at Ser-165 is likely to be required for secretion. |
| Function | Isoform 1: Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein. Isoform 2: Does not have mitogenic activity for fibroblasts. Does not bind heparin. Isoform 3: Has mitogenic activity for fibroblasts. Heparin-binding protein. |
| Protein Name | Hepatoma-Derived Growth FactorHdgfHigh Mobility Group Protein 1-Like 2Hmg-1l2 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Isoform 1: NucleusCytoplasmSecretedExtracellular ExosomeSecreted By Exosomes And Is Located Inside The ExosomeMay Also Be Secreted As Free Protein Via An As Yet Unknown PathwayIsoform 2: NucleusSecreted By Exosomes And Is Located On The Outer Exosome SurfaceIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Hepatoma-Derived Growth Factor antibodyAnti-Hdgf antibodyAnti-High Mobility Group Protein 1-Like 2 antibodyAnti-Hmg-1l2 antibodyAnti-HDGF antibodyAnti-HMG1L2 antibody |
Information sourced from Uniprot.org
