• Western blot analysis of lysates from HepG2 cells, using HDAC9 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using HDAC9 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of HepG2 cells using Histone deacetylase 9 Polyclonal Antibody diluted at 1：1000
  • Immunofluorescence analysis of HepG2 cells, using HDAC9 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Histone deacetylase 9 Polyclonal Antibody diluted at 1：1000

Anti-HDAC9 antibody (1017-1066 aa) (STJ93514)

SKU:
STJ93514

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Histone deacetylase 9 (1017-1066 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HDAC9
Gene ID: 9734
Uniprot ID: HDAC9_HUMAN
Immunogen Region: 1017-1066 aa
Specificity: Histone deacetylase 9 Polyclonal Antibody detects endogenous levels of Histone deacetylase 9 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HDAC9 at the amino acid range 1017-1066
Post Translational Modifications Phosphorylated on Ser-220 and Ser-450.which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240.which impairs nuclear accumulation. Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Sumoylated.
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Protein Name Histone Deacetylase 9
Hd9
Histone Deacetylase 7b
Hd7
Hd7b
Histone Deacetylase-Related Protein
Mef2-Interacting Transcription Repressor Mitr
Database Links Reactome: R-HSA-2122947
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-350054
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Histone Deacetylase 9 antibody
Anti-Hd9 antibody
Anti-Histone Deacetylase 7b antibody
Anti-Hd7 antibody
Anti-Hd7b antibody
Anti-Histone Deacetylase-Related Protein antibody
Anti-Mef2-Interacting Transcription Repressor Mitr antibody
Anti-HDAC9 antibody
Anti-HDAC7 antibody
Anti-HDAC7B antibody
Anti-HDRP antibody
Anti-KIAA0744 antibody
Anti-MITR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance