| Short Description : | Rabbit polyclonal anti-Polyamine deacetylase HDAC10 (10-59 aa) for use in WB, IHC, IF and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HDAC10 |
| Gene ID: | 83933 |
| Uniprot ID: | HDA10_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human HDAC10 at the amino acid range 10-59 |
| Immunogen Region: | 10-59 aa |
| Specificity: | Histone deacetylase 10 Polyclonal Antibody detects endogenous levels of Histone deacetylase 10 protein. |
| Function | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair. |
| Protein Name | Polyamine Deacetylase Hdac10Histone Deacetylase 10Hd10 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054 |
| Cellular Localisation | CytoplasmNucleusExcluded From Nucleoli |
| Alternative Antibody Names | Anti-Polyamine Deacetylase Hdac10 antibodyAnti-Histone Deacetylase 10 antibodyAnti-Hd10 antibodyAnti-HDAC10 antibody |
Information sourced from Uniprot.org
