| Post Translational Modifications | O-GlcNAcylation increases the hyaluronan synthase activity, HAS3 stability and its plasma membrane residence. The concentration of UDP-GlcNAc controls the level of O-GlcNAc modification. |
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. |
| Protein Name | Hyaluronan Synthase 3Hyaluronate Synthase 3Hyaluronic Acid Synthase 3Ha Synthase 3 |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneGolgi ApparatusTrans-Golgi Network MembraneEarly EndosomeTravels From Endoplasmic Reticulum (Er)Golgi To Plasma MembraneActives Only When Present In Plasma MembraneO-Glcnacylation Controls Its Membrane LocalizationA Rapid Recycling Of Has3 Between Plasma Membrane And Endosomes Is Controlled By The Cytosolic Levels Of Udp-Glcua And Udp-Glcnac |
| Alternative Antibody Names | Anti-Hyaluronan Synthase 3 antibodyAnti-Hyaluronate Synthase 3 antibodyAnti-Hyaluronic Acid Synthase 3 antibodyAnti-Ha Synthase 3 antibodyAnti-HAS3 antibody |
Information sourced from Uniprot.org
