Anti-GYS2 antibody (26-76) (STJA0006602)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GYS2 AA range: 26-76
General Information
| Short Description | Rabbit polyclonal anti-Glycogen synthase, liver (26-76) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GYS2 |
| Gene ID | 2998 |
| Uniprot ID | GYS2_HUMAN |
| Immunogen | Synthesized peptide derived from human GYS2 AA range: 26-76 |
| Immunogen Region | 26-76 |
| Specificity | This antibody detects endogenous levels of human GYS2 |
Additional Info
| Post Translational Modifications | Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. Phosphorylation at Ser-8 is not required for interaction with GYG1. Interaction with GYG1 does not regulate the phosphorylation at Ser-8 and Ser-641. |
| Function | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
| Protein Name | Glycogen Starch Synthase - LiverGlycogen Synthase 2 |
| Database Links | Reactome: R-HSA-3322077Reactome: R-HSA-3858516Reactome: R-HSA-3878781 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Glycogen Starch Synthase - Liver antibodyAnti-Glycogen Synthase 2 antibodyAnti-GYS2 antibody |
Information sourced from Uniprot.org