| Host: |
Mouse |
| Applications: |
WB/FC/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Glycogen synthase, muscle is suitable for use in Western Blot, Flow Cytometry and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
3A7 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000FC 1:200-1:400ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GYS1 |
| Gene ID: |
2997 |
| Uniprot ID: |
GYS1_HUMAN |
| Specificity: |
Glycogen Synthase 1 Monoclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein. |
| Immunogen: |
Purified recombinant fragment of human Glycogen Synthase 1 expressed in E. Coli. |
| Post Translational Modifications | Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Phosphorylated at Ser-641 by PASK, leading to inactivation.phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. |
| Function | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
| Protein Name | Glycogen Starch Synthase - MuscleGlycogen Synthase 1 |
| Database Links | Reactome: R-HSA-3322077Reactome: R-HSA-3785653Reactome: R-HSA-3814836Reactome: R-HSA-3828062 |
| Alternative Antibody Names | Anti-Glycogen Starch Synthase - Muscle antibodyAnti-Glycogen Synthase 1 antibodyAnti-GYS1 antibodyAnti-GYS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
