![Anti-GYS1 antibody [3A7] (STJ98112)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/120261/229950/STJ98112_3_ELISA__14363.1602854561.jpg?c=1 "Anti-GYS1 antibody [3A7] (STJ98112)")
Anti-GYS1 antibody [3A7] (STJ98112)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human Glycogen Synthase 1 expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Glycogen synthase, muscle for use in WB, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3A7 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000FC 1:200-1:400ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GYS1 |
| Gene ID | 2997 |
| Uniprot ID | GYS1_HUMAN |
| Immunogen | Purified recombinant fragment of human Glycogen Synthase 1 expressed in E. Coli. |
| Specificity | Glycogen Synthase 1 Monoclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein. |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Phosphorylated at Ser-641 by PASK, leading to inactivation.phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. |
| Function | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
| Protein Name | Glycogen Starch Synthase - MuscleGlycogen Synthase 1 |
| Database Links | Reactome: R-HSA-3322077Reactome: R-HSA-3785653Reactome: R-HSA-3814836Reactome: R-HSA-3828062 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Glycogen Starch Synthase - Muscle antibodyAnti-Glycogen Synthase 1 antibodyAnti-GYS1 antibodyAnti-GYS antibody |
Information sourced from Uniprot.org