Flow cytometric analysis of K562 cells using Glycogen Synthase 1 monoclonal antibody (green) and negative control (purple).

Anti-GYS1 antibody [3A7] (STJ98112)

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STJ98112
€178.80 - €432.00
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Short Description :Mouse monoclonal anti-Glycogen synthase, muscle for use in WB, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/FC/ELISA
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :3A7
Isotype:IgG1
Conjugation:Unconjugated
Purification:Affinity purification
Dilution Range:WB 1:500-1:2000
FC 1:200-1:400
ELISA 1:10000
Formulation:Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:GYS1
Gene ID:2997
Uniprot ID:GYS1_HUMAN
Immunogen:Purified recombinant fragment of human Glycogen Synthase 1 expressed in E. Coli.
Specificity:Glycogen Synthase 1 Monoclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein.
Post Translational Modifications Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Phosphorylated at Ser-641 by PASK, leading to inactivation.phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.
Function Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Protein Name Glycogen Starch Synthase - Muscle
Glycogen Synthase 1
Database Links Reactome: R-HSA-3322077
Reactome: R-HSA-3785653
Reactome: R-HSA-3814836
Reactome: R-HSA-3828062
Cellular Localisation
Alternative Antibody Names Anti-Glycogen Starch Synthase - Muscle antibody
Anti-Glycogen Synthase 1 antibody
Anti-GYS1 antibody
Anti-GYS antibody

Information sourced from Uniprot.org

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