Anti-GTPBP3 antibody (STJA0007693)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GTPBP3
General Information
| Short Description | Rabbit polyclonal anti-tRNA modification GTPase GTPBP3, mitochondrial for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GTPBP3 |
| Gene ID | 84705 |
| Uniprot ID | GTPB3_HUMAN |
| Immunogen | Synthesized peptide derived from human GTPBP3 |
| Specificity | This antibody detects endogenous levels of GTPBP3 at Human, Mouse, Rat |
Additional Info
| Function | GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity. |
| Protein Name | 5-Taurinomethyluridine-Trna Synthase Subunit Gtpb3 - MitochondrialGtp-Binding Protein 3Mitochondrial Gtp-Binding Protein 1Trna Modification Gtpase Gtpbp3 - Mitochondrial |
| Database Links | Reactome: R-HSA-6787450 |
| Cellular Localisation | MitochondrionIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-5-Taurinomethyluridine-Trna Synthase Subunit Gtpb3 - Mitochondrial antibodyAnti-Gtp-Binding Protein 3 antibodyAnti-Mitochondrial Gtp-Binding Protein 1 antibodyAnti-Trna Modification Gtpase Gtpbp3 - Mitochondrial antibodyAnti-GTPBP3 antibodyAnti-MTGP1 antibody |
Information sourced from Uniprot.org