| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GTF2A1 |
| Gene ID: | 2957 |
| Uniprot ID: | TF2AA_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human GTF2A1 (NP_056943.1). |
| Immunogen Sequence: | MANSANTNTVPKLYRSVIED VINDVRDIFLDDGVDEQVLM ELKTLWENKLMQSRAVDGFH SEEQQLLLQVQQQHQPQQQQ HHHHHHHQQAQPQQTVPQQA QTQQVLIPASQQATAPQVIV PDSKLIQHMNASNMSAAATA ATLALPAGVTPVQQILTNSG QLLQVVRAANGAQYIFQPQQ SVVLQQQVIPQMQPGGVQAP VIQQVLAPLPGGISPQTGVI IQPQQILFTGNKTQVIPTT |
| Post Translational Modifications | The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation. |
| Function | TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. |
| Protein Name | Transcription Initiation Factor Iia Subunit 1General Transcription Factor Iia Subunit 1TfiialTranscription Initiation Factor Tfiia 42 Kda SubunitTfiia-42 Cleaved Into - Transcription Initiation Factor Iia Alpha ChainTfiia P35 Subunit - Transcription Initiation Factor Iia Beta ChainTfiia P19 Subunit |
| Database Links | Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-674695Reactome: R-HSA-6807505Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-75953Reactome: R-HSA-76042Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Initiation Factor Iia Subunit 1 antibodyAnti-General Transcription Factor Iia Subunit 1 antibodyAnti-Tfiial antibodyAnti-Transcription Initiation Factor Tfiia 42 Kda Subunit antibodyAnti-Tfiia-42 Cleaved Into - Transcription Initiation Factor Iia Alpha Chain antibodyAnti-Tfiia P35 Subunit - Transcription Initiation Factor Iia Beta Chain antibodyAnti-Tfiia P19 Subunit antibodyAnti-GTF2A1 antibodyAnti-TF2A1 antibody |
Information sourced from Uniprot.org
