Anti-GRIPAP1 antibody (STJA0007934)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GRIPAP1
General Information
| Short Description | Rabbit polyclonal anti-GRIP1-associated protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRIPAP1 |
| Gene ID | 56850 |
| Uniprot ID | GRAP1_HUMAN |
| Immunogen | Synthesized peptide derived from human GRIPAP1 |
| Specificity | This antibody detects endogenous levels of GRIPAP1 at Human, Mouse, Rat |
Additional Info
| Function | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. GRASP-1 C-terminal chain: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. |
| Protein Name | Grip1-Associated Protein 1Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain30kda C-Terminus Form |
| Database Links | |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinRecycling Endosome MembraneCell ProjectionAxonDendriteSynapseLocalizes To Recycling Endosomal Tubules That Are Emanating From Early Endosomes |
| Alternative Antibody Names | Anti-Grip1-Associated Protein 1 antibodyAnti-Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain antibodyAnti-30kda C-Terminus Form antibodyAnti-GRIPAP1 antibodyAnti-KIAA1167 antibody |
Information sourced from Uniprot.org