Anti-GRIA4 antibody (828-877 aa) (STJ93289)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GluR4 at the amino acid range 828-877
General Information
| Short Description | Rabbit polyclonal anti-Glutamate receptor 4 (828-877 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRIA4 |
| Gene ID | 2893 |
| Uniprot ID | GRIA4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GluR4 at the amino acid range 828-877 |
| Immunogen Region | 828-877 aa |
| Specificity | GluR4 Polyclonal Antibody detects endogenous levels of GluR4 protein. |
Additional Info
| Function | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. |
| Protein Name | Glutamate Receptor 4Glur-4Glur4Ampa-Selective Glutamate Receptor 4Glur-DGlutamate Receptor Ionotropic - Ampa 4 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Glutamate Receptor 4 antibodyAnti-Glur-4 antibodyAnti-Glur4 antibodyAnti-Ampa-Selective Glutamate Receptor 4 antibodyAnti-Glur-D antibodyAnti-Glutamate Receptor Ionotropic - Ampa 4 antibodyAnti-GRIA4 antibodyAnti-GluA4 antibodyAnti-GLUR4 antibody |
Information sourced from Uniprot.org