| Function | Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 6.8-7.2. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR4 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also couple with G(q) and G(12)/G(13) G proteins. Acts as a key regulator of respiratory sensitivity to CO2/H(+) in brain retrotrapezoid nucleus neurons: acts by mediating detection of protons generated by the formation of carbonic acid in the blood, an important mechanism to impulse to breathe. Also acts as a regulator of acid secretion in the kidney collecting duct by maintaining acid-base homeostasis in the kidney. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells, possibly through the G(12)/G(13)/Rho GTPase signaling pathway. |
| Protein Name | G-Prodeshotein Coupled Receptor 4Hgpr4G-Protein Coupled Receptor 6c.lGpr6c.l |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G-Prodeshotein Coupled Receptor 4 antibodyAnti-Hgpr4 antibodyAnti-G-Protein Coupled Receptor 6c.l antibodyAnti-Gpr6c.l antibodyAnti-GPR4 antibody |
Information sourced from Uniprot.org
