| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPR4 |
| Gene ID: | 2828 |
| Uniprot ID: | GPR4_HUMAN |
| Immunogen Region: | 283-362 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 283-362 of human GPR4 (NP_005273.1). |
| Immunogen Sequence: | PILYCLVNEGARSDVAKALH NLLRFLASDKPQEMANASLT LETPLTSKRNSTAKAMTGSW AATPPSQGDQVQLKMLPPAQ |
| Function | Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)H(+). |
| Protein Name | G-Protein Coupled Receptor 4G-Protein Coupled Receptor 6c.lGpr6c.l |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 4 antibodyAnti-G-Protein Coupled Receptor 6c.l antibodyAnti-Gpr6c.l antibodyAnti-GPR4 antibody |
Information sourced from Uniprot.org