| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPR35 |
| Gene ID: |
2859 |
| Uniprot ID: |
GPR35_HUMAN |
| Immunogen Region: |
50-150 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GPR35 (NP_005292.2). |
| Immunogen Sequence: |
QQWTETRIYMTNLAVADLCL LCTLPFVLHSLRDTSDTPLC QLSQGIYLTNRYMSISLVTA IAVDRYVAVRHPLRARGLRS PRQAAAVCAVLWVLVIGSLV A |
| Tissue Specificity | Predominantly expressed in immune and gastrointestinal tissues. |
| Post Translational Modifications | Multiply phosphorylated in clusters of serines and threonines in the C-terminal tail. Phosphorylation of Ser-300 and Ser-303 is mediated by GRK5 and/or GRK6. |
| Function | G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand. Stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue once activated by kynurenic acid. In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages. |
| Protein Name | G-Protein Coupled Receptor 35Kynurenic Acid ReceptorKyna Receptor |
| Database Links | Reactome: R-HSA-373076 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized To The Cytoplasm After Exposure To Kynurenic Acid |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 35 antibodyAnti-Kynurenic Acid Receptor antibodyAnti-Kyna Receptor antibodyAnti-GPR35 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
