| Post Translational Modifications | Phosphorylation is necessary for YWHAE binding and efficient surface expression. O-glycosylated. Sialylated O-glycans in the N-terminal tail inhibits binding of GPR15LG. Sulfation is required for efficient binding of GPR15LG. |
| Function | G protein-coupled receptor that plays an important role in immune homeostasis. Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells. Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria. Also required for skin localization of thymus-derived dendritic epidermal T-cells. Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin. Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. (Microbial infection) Acts as an alternative coreceptor with CD4 for HIV-1 infection. |
| Protein Name | G-Protein Coupled Receptor 15Brother Of BonzoBob |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 15 antibodyAnti-Brother Of Bonzo antibodyAnti-Bob antibodyAnti-GPR15 antibody |
Information sourced from Uniprot.org
