| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNS |
| Gene ID: | 2799 |
| Uniprot ID: | GNS_HUMAN |
| Immunogen Region: | 293-552 |
| Immunogen Sequence: | WQTLLSVDDLVEKLVKRLEF TGELNNTYIFYTSDNGYHTG QFSLPIDKRQLYEFDIKVPL LVRGPGIKPNQTSKMLVANI DLGPTILDIAGYDLNKTQMD GMSLLPILRGASNLTWRSDV LVEYQGEGRNVTDPTCPSLS PGVSQCFPDCVCEDAYNNTY ACVRTMSALWNLQYCEFDDQ EVFVEVYNLTADPDQITNIA KTIDPELLGKMNYRLMMLQS CSGPTCRTPGVFDPGYRFD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 293-552 of human GNS (NP_002067.1). |
| Post Translational Modifications | The form A (78 kDa) is processed by internal peptidase cleavage to a 32 kDa N-terminal species (form B) and a 48 kDa C-terminal species. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Function | Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate. |
| Protein Name | N-Acetylglucosamine-6-SulfataseGlucosamine-6-SulfataseG6s |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2206305Reactome: R-HSA-432720Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-N-Acetylglucosamine-6-Sulfatase antibodyAnti-Glucosamine-6-Sulfatase antibodyAnti-G6s antibodyAnti-GNS antibody |
Information sourced from Uniprot.org
