Western blot analysis of various lysates using GNPDA1 Rabbit polyclonal antibody (STJ115671) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-GNPDA1 antibody (1-70) (STJ115671)

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STJ115671
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GNPDA1
Gene ID: 10007
Uniprot ID: GNPI1_HUMAN
Immunogen Region: 1-70
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human GNPDA1 (NP_005462.1).
Immunogen Sequence: MKLIILEHYSQASEWAAKYI RNRIIQFNPGPEKYFTLGLP TGSTPLGCYKKLIEYYKNGD LSFKYVKTFN
Function Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo.
Protein Name Glucosamine-6-Phosphate Isomerase 1
Glucosamine-6-Phosphate Deaminase 1
Gnpda 1
Glcn6p Deaminase 1
Oscillin
Database Links Reactome: R-HSA-70171
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Glucosamine-6-Phosphate Isomerase 1 antibody
Anti-Glucosamine-6-Phosphate Deaminase 1 antibody
Anti-Gnpda 1 antibody
Anti-Glcn6p Deaminase 1 antibody
Anti-Oscillin antibody
Anti-GNPDA1 antibody
Anti-GNPI antibody
Anti-HLN antibody
Anti-KIAA0060 antibody

Information sourced from Uniprot.org

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