| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Guanine nucleotide-binding protein Gt subunit alpha-1 (71-120 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GNAT1 |
| Gene ID: |
2779 |
| Uniprot ID: |
GNAT1_HUMAN |
| Immunogen Region: |
71-120 aa |
| Specificity: |
G Alpha t1 Polyclonal Antibody detects endogenous levels of G Alpha t1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human GNAT1 at the amino acid range 71-120 |
| Function | Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase. |
| Protein Name | Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1Transducin Alpha-1 Chain |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859Reactome: R-HSA-418594 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentMembranePeripheral Membrane ProteinPhotoreceptor Inner SegmentLocalizes Mainly In The Outer Segment In The Dark-Adapted StateWhereas Is Translocated To The Inner Part Of The Photoreceptors In The Light-Adapted StateDuring Dark-Adapted ConditionsIn The Presence Of Unc119 Mislocalizes From The Outer Segment To The Inner Part Of Rod Photoreceptors Which Leads To Decreased Photoreceptor Damage Caused By Light |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1 antibodyAnti-Transducin Alpha-1 Chain antibodyAnti-GNAT1 antibodyAnti-GNATR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
