Anti-GLYR1 antibody (70-270) (STJ111541)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GLYR1 (70-270) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLYR1 |
| Gene ID | 84656 |
| Uniprot ID | GLYR1_HUMAN |
| Immunogen Region | 70-270 |
| Immunogen Sequence | MIKINKGKRFQQAVDAVEEF LRRAKGKDQTSSHNSSDDKN RRNSSEERSRPNSGDEKRKL SLSEGKVKKNMGEGKKRVSS GSSERGSKSPLKRAQEQSPR KRGRPPKDEKDLTIPESSTV KGMMAGPMAAFKWQPTASEP VKDADPHFHHFLLSQTEKPA VCYQAITKKLKICEEETGST SIQAADSTAVNGSITPTDKK I |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 70-270 of human GLYR1 (NP_115958.2). |
Additional Info
| Function | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation. Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. |
| Protein Name | Cytokine-Like Nuclear Factor N-PacNpac3-Hydroxyisobutyrate Dehydrogenase-Like ProteinGlyoxylate Reductase 1 HomologNuclear Protein Np60Nuclear Protein Of 60 KdaNucleosome-Destabilizing FactorHndfPutative Oxidoreductase Glyr1 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeFound In Actively Rnapolii-Transcribed Gene Bodies |
| Alternative Antibody Names | Anti-Cytokine-Like Nuclear Factor N-Pac antibodyAnti-Npac antibodyAnti-3-Hydroxyisobutyrate Dehydrogenase-Like Protein antibodyAnti-Glyoxylate Reductase 1 Homolog antibodyAnti-Nuclear Protein Np60 antibodyAnti-Nuclear Protein Of 60 Kda antibodyAnti-Nucleosome-Destabilizing Factor antibodyAnti-Hndf antibodyAnti-Putative Oxidoreductase Glyr1 antibodyAnti-GLYR1 antibodyAnti-HIBDL antibodyAnti-NDF antibodyAnti-NP60 antibodyAnti-NPAC antibody |
Information sourced from Uniprot.org