| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Zinc finger protein GLIS2 (442-492 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GLIS2 |
| Gene ID: | 84662 |
| Uniprot ID: | GLIS2_HUMAN |
| Immunogen Region: | 442-492 aa |
| Specificity: | This antibody detects endogenous levels of GLIS2 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human GLIS2 at the amino acid range 442-492 |
| Post Translational Modifications | C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase. |
| Function | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. |
| Protein Name | Zinc Finger Protein Glis2Gli-Similar 2Neuronal Krueppel-Like Protein |
| Database Links | |
| Cellular Localisation | Nucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Protein Glis2 antibodyAnti-Gli-Similar 2 antibodyAnti-Neuronal Krueppel-Like Protein antibodyAnti-GLIS2 antibodyAnti-NKL antibody |
Information sourced from Uniprot.org
