Anti-GLDN antibody (461-511 aa) (STJ194992)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GLDN at the amino acid range 461-511
General Information
| Short Description | Rabbit polyclonal anti-Gliomedin (461-511 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLDN |
| Gene ID | 342035 |
| Uniprot ID | GLDN_HUMAN |
| Immunogen | Synthesized peptide derived from the human GLDN at the amino acid range 461-511 |
| Immunogen Region | 461-511 aa |
| Specificity | This antibody detects endogenous levels of GLDN at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | N-glycosylated. Proteolytic processing by a furin-like protease causes shedding of the ectodomain. Further cleavage by BMP1 releases the olfactomedin-like domain. |
| Function | Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes.not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. |
| Protein Name | Gliomedin Cleaved Into - Gliomedin Shedded Ectodomain |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCell ProjectionAxonDetected At The Nodes Of RanvierDetected At Immature HeminodesGliomedin Shedded Ectodomain: SecretedSecretedExtracellular SpaceExtracellular MatrixProteolytic Processing Gives Rise To A Soluble Extracellular Domain That Is SecretedThe Gliomedin Shedded Ectodomain Localizes To The Nodes Of Ranvier |
| Alternative Antibody Names | Anti-Gliomedin Cleaved Into - Gliomedin Shedded Ectodomain antibodyAnti-GLDN antibodyAnti-COLM antibodyAnti-UNQ9339 antibodyAnti-PRO34011 antibody |
Information sourced from Uniprot.org