| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Beta-galactosidase (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GLB1 |
| Gene ID: | 2720 |
| Uniprot ID: | BGAL_HUMAN |
| Immunogen Region: | Internal |
| Specificity: | Galactosidase Beta Polyclonal Antibody detects endogenous levels of Galactosidase Beta protein. |
| Immunogen: | Synthesized peptide derived from the Internal region of human Galactosidase Beta. |
| Function | Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. |
| Protein Name | Beta-Galactosidase Acid Beta-Galactosidase Lactase Elastin Receptor 1 |
| Database Links | Reactome: R-HSA-2022857 Reactome: R-HSA-2024096 Reactome: R-HSA-2206308 Reactome: R-HSA-4085001 Reactome: R-HSA-4341670 Reactome: R-HSA-6798695 Reactome: R-HSA-9840310 |
| Cellular Localisation | Isoform 1: Lysosome Isoform 2: Cytoplasm Perinuclear Region Localized To The Perinuclear Area Of The Cytoplasm But Not To Lysosomes |
| Alternative Antibody Names | Anti-Beta-Galactosidase antibody Anti-Acid Beta-Galactosidase antibody Anti-Lactase antibody Anti-Elastin Receptor 1 antibody Anti-GLB1 antibody Anti-ELNR1 antibody |
Information sourced from Uniprot.org