Anti-GJA8 antibody (234-433) (STJ11103022)

Name: Anti-GJA8 antibody (234-433) (STJ11103022)
SKU: STJ11103022
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103022

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Short Description	Rabbit polyclonal GJA8 (234-433) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	GJA8
Gene ID	2703
Uniprot ID	CXA8_HUMAN
Immunogen Region	234-433
Immunogen Sequence	SALKRPVEQPLGEIPEKSLH SIAVSSIQKAKGYQLLEEEK IVSHYFPLTEVGMVETSPLP AKPFNQFEEKISTGPLGDLS RGYQETLPSYAQVGAQEVEG EGPPAEEGAEPEVGEKKEEA ERLTTEEQEKVAVPEGEKVE TPGVDKEGEKEEPQSEKVSK QGLPAEKTPSLCPELTTDDA RPLSRLSKASSRARSDDLTV
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 234-433 of human GJA8 (NP_005258.2).

Tissue Specificity	Eye lens.
Function	Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Protein Name	Gap Junction Alpha-8 Protein Connexin-50 Cx50 Lens Fiber Protein Mp70
Database Links	Reactome: R-HSA-190861
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Junction Gap Junction
Alternative Antibody Names	Anti-Gap Junction Alpha-8 Protein antibody Anti-Connexin-50 antibody Anti-Cx50 antibody Anti-Lens Fiber Protein Mp70 antibody Anti-GJA8 antibody

Information sourced from Uniprot.org